Detection of Gliotoxin in Experimental and Human Aspergillosis
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چکیده
منابع مشابه
hydrochlorothiazide detection in urine samples by hplc-dad and experimental design dispersive l-l microextraction
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Disseminated aspergillosis in an immunocompetent patient with detectable bis(methylthio)gliotoxin and negative galactomannan.
BACKGROUND Disseminated invasive aspergillosis is an exceptional finding in immunocompetent hosts. As in immunocompromised patients, it has high mortality rates. Early diagnostic methods are required in order to properly manage the patient. Bis(methylthio)gliotoxin (bmGT) is a novel biomarker, useful in onco-hematological patients. CASE REPORT A 70-year-old male, with non-insulin dependent ty...
متن کاملEffect of gliotoxin on human polymorphonuclear neutrophils.
OBJECTIVES Candida albicans is known to produce gliotoxin, which has several prominent biological effects, including immunosuppression. Interference with host defenses may arise from the effects of this toxin on leukocyte structure and function. METHODS Flow cytometric analysis revealed that polymorphonuclear leukocytes (PMN) were more sensitive to gliotoxin than were mononuclear cells. Struc...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 2005
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.73.1.635-637.2005